News

G Protein-Coupled Receptors: A New Target for Monoclonal Antibodies.

G protein-coupled receptors (GPCRs) are a large family of proteins that play important roles in human health and disease. Roughly one third of all approved medicines work by targeting a GPCR however, historically none of these medicines have been monoclonal antibodies.

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Figure 1: Activation of the G alpha subunit of a G-protein-coupled receptor In unstimulated cells, the state of G alpha (orange circles) is defined by its interaction with GDP, G beta-gamma (purple circles), and a G-protein-coupled receptor (GPCR; light green loops). Upon receptor stimulation by a ligand called an agonist, the state of the receptor changes. G alpha dissociates from the receptor and G beta-gamma, and GTP is exchanged for the bound GDP, which leads to G alpha activation. G alpha then goes on to activate other molecules in the cell. © 2002 Nature Publishing Group Li, J. et al. The Molecule Pages database. Nature 420, 716-717 (2002). All rights reserved.

Research

Lecanemab: A New Hope for Alzheimer’s Patients.

The road to effective treatments for Alzheimer’s disease has been littered with failures. However, clinical trials of lecanemab supported by Bath ASU have been heralded [...]

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Student Exam Success…

Congratulations to our University placement students Sofia, and Shannon who have passed their NCFE Level 2 Awards in Aseptic Services.

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Research

Is This the End of the “mabs”?

The first monoclonal antibody to achieve marketing approval was Muromonab in 1986. Since then, monoclonal antibodies have become one of the most successful classes of [...]

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ADCs: What are they and why do they matter?

This is the first article in a series of five blog posts that will put the ADCs in the spotlight. This article will summarise ADCs [...]

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ADCs: Function & Pharmacology

This is the second article in a series of five blog posts that are putting ADCs in the spotlight. This article will describe in detail [...]

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ADCs: Pros and Cons

This is the third article in a series of five blog posts that are putting ADCs in the spotlight. This article will describe the pros [...]

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ADCs: Origins and Obstacles

This is the fourth article in a series of five blog posts that are putting ADCs in the spotlight. This article will describe the origins [...]

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ADCs: Pipeline and Progress

This is the fifth article in a series of five blog posts that are putting ADCs in the spotlight. This article will describe ways in [...]

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ADC Structure, Safety & Stability, from the 2015 NHS QA Symposium

Dr Benjamin Young and Terry Chapman spoke at the annual NHS QA Symposium on 15th September 2015. These are the slides from their talk.

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Article Reviews

Research

Monoclonal Antibodies to Mitigate Migraine

Chronic migraine is a debilitating disorder that affects roughly one in fifty people globally with the cost to the National Health Service in the UK [...]

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Research

Sirukumab Set to Establish New Field

The success of protein-based drugs has seen them impact on almost every branch of modern medicine. They are useful modulators of the immune system and [...]

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